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- *****************************
- * HMG14 and HMG17 signature *
- *****************************
-
- High mobility group (HMG) proteins are a family of relatively low molecular
- weight non-histone components in chromatin. HMG14 and HMG17 [1], two related
- proteins of about 100 amino acid residues, bind to the inner side of the
- nucleosomal DNA thus altering the interaction between the DNA and the histone
- octamer. These two proteins may be involved in the process which maintains
- transcribable genes in a unique chromatin conformation.
-
- The trout nonhistone chromosomal protein H6 (histone T) also belongs to this
- family.
-
- As a signature pattern we selected a conserved stretch of 10 residues located
- in the N-terminal section of HMG14 and HMG17.
-
- -Consensus pattern: R-R-S-A-R-L-S-A-[RK]-P
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Expert(s) to contact by email: Landsman D.
- landsman@ncbi.nlm.nih.gov
-
- -Last update: May 1991 / Text revised.
-
- [ 1] Bustin M., Lehn D.A., Landsman D.
- Biochim. Biophys. Acta 1049:231-243(1990).
-